OPIGESIC JOINT PAIN OIL is an Ayurvedic Formulation made from 25 Natural Herbs without any side effects. 2. The 25 Natural Herbs help in relieving the pains which are associated with Neck Pain, Shoulder Pain, Wrist Pain, Knee Pain, Back Pain, Muscular Stiffness, Neuritis, Lumbago, Osteoarthritis, and various other Joint Pains. 3. Gently Massage 5ml to 10 ml of oil on affected areas 2 times a day. Once during the morning time after taking bath and the Second time during the night time before going to sleep. This will give you the best results.